The Middle East is the part of the world, in southwestern Asia, between the Mediterranean Sea and the Indian subcontinent, where America's oil is buried under the desert sands nominally held by her arch-enemies. The region is overwhelmingly Muslim and has of late had a tumultuous history.
Ironically, America's one true ally in the region, Israel, has none of this oil (although Kuwait is US friendly and has oodles of oil).
The term is presently synonymous with the term "Near East" - while the Far East is (sensibly) as far away as possible from the area.
 See also
- Midwest, which is a contraction of "Middle" and "West" and out of some weird coincidence contains a state that contains a region called Little Egypt and a small town called Palestine.