List of antidepressants

From Wikipedia, the free encyclopedia

This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification. Chemical/generic names are listed first, with brand names in parentheses. All drugs listed are approved specifically for major depressive disorder unless noted otherwise.

Selective serotonin reuptake inhibitors (SSRIs)[edit]

Discontinued/withdrawn[edit]

Serotonin–norepinephrine reuptake inhibitors (SNRIs)[edit]

Serotonin–norepinephrine–dopamine reuptake inhibitors (SNDRIs)[edit]

Serotonin modulators and stimulators (SMSs)[edit]

Serotonin antagonist and reuptake inhibitors (SARIs)[edit]

  • Nefazodone (Dutonin, Nefadar, Serzone) – withdrawn/discontinued in most countries
  • Trazodone (Desyrel)

Discontinued/withdrawn[edit]

Norepinephrine reuptake inhibitors (NRIs)[edit]

Off-label only[edit]

Norepinephrine–dopamine reuptake inhibitors (NDRIs)[edit]

Off-label only[edit]

Discontinued/withdrawn[edit]

Tricyclic antidepressants (TCAs)[edit]

Opipramol (Insidon), tianeptine (Stablon, Coaxil) and amineptine (discontinued; formerly Survector, Maneon) are chemically TCAs but are pharmacodynamically atypical, and are therefore grouped elsewhere.

Discontinued/withdrawn[edit]

Tetracyclic antidepressants (TeCAs)[edit]

Mianserin, mirtazapine, and setiptiline are also sometimes described as noradrenergic and specific serotonergic antidepressants (NaSSAs).

Monoamine oxidase inhibitors (MAOIs)[edit]

Irreversible[edit]

Non-selective[edit]

Discontinued/withdrawn

Selective for MAO-B[edit]

Reversible[edit]

Non-selective[edit]

Discontinued/withdrawn

Selective for MAO-A[edit]

These drugs are sometimes described as reversible inhibitors of MAO-A (RIMAs).

Discontinued/withdrawn

Mixed[edit]

Non-selective[edit]

  • Bifemelane (Alnert, Celeport) – RIMA, irreversible inhibitor of MAO-B, and weak NRI

Atypical antipsychotics[edit]

Others[edit]

Marketed[edit]

Off-label only[edit]

Discontinued/withdrawn[edit]

Over-the-counter[edit]

The following antidepressants are available both with a prescription and over-the-counter:

Adjunctive treatments[edit]

Atypical antipsychotics[edit]

  • Aripiprazole (Abilify) – approved as an adjunct to antidepressant for major depression
  • Brexpiprazole (Rexulti) – approved as an adjunct to antidepressant for major depression
  • Lumateperone (Caplyta) – approved as an adjunct to mood stabilizer for bipolar depression
  • Lurasidone (Latuda) – approved as an adjunct to mood stabilizer for bipolar depression
  • Olanzapine (Zyprexa) – approved as an adjunct to antidepressant for major depression
  • Quetiapine (Seroquel) – approved as an adjunct to antidepressant or mood stabilizer for major depression and bipolar depression

Off-label only[edit]

Typical antipsychotics[edit]

Off-label only[edit]

Others[edit]

Off-label only[edit]

Combination products[edit]

References[edit]

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