Ayahuasca

Ayahuasca (a.k.a. yagé) is a hallucinogenic and entheogenic concoction used ceremonially in certain Peruvian and Brazilian religions. The use of ayahuasca was first described outside of South American communities in the 1950s by ethnobotanist Richard Evans Schultes.

Users of ayahuasca describe having "profound life-changing spiritual experiences," and "a sense of inner peace and acceptance of self, others, and the world." However, it also makes you vomit and shit, and basically feel terrible. At first you're afraid you're going to die, then you're afraid you're not going to die. In recent years, people from other countries have been traveling to South America to have such an experience. This is ayahuasca tourism. Some shamans charge a whole heap of money for their goods and services.

Pharmacology
The active ingredient is (DMT), which is a Schedule I substance in the USA. DMT, also known as "the spirit molecule", is normally metabolized in the stomach by monoamine oxidase (MAO), and so never reaches the bloodstream; but those cunning shamans long ago discovered that a monoamine oxidase inhibitor (MAOI) prevents first pass metabolism of DMT, which in turn allows the full effect of the DMT to be felt. As luck would have it, DMT is plentiful in shrubs of the Psychotria genus, and MAOI can be found in a jungle vine of the Malpighiaceae family (e.g., Banisteriopsis caapi). Let the party begin.

Benefits and dangers
Claimed benefits are roughly the same as for LSD and other psychedelic hallucinogens &mdash; namely, that it produces experiences described as being "spiritual" or "life-changing" in nature. MAPS has also conducted a preliminary observational study suggesting that ayahuasca may be helpful for treating certain aspects of addiction.

Complications include death, cardiac arrhythmia caused by the harmala alkaloids, and acute psychosis. Documented social dangers include rape of female ayahuascarians and, obviously, daylight robbery of the rich by the poor, which is arguably a benefit. There have been reports of other hallucinogens being mixed in (usually plants which contain scopolamine), to give the turistas "that extra buzz".

As the harmala alkaloids in ayahuasca are MAOIs, they strongly potentiate Specifically, they allow serotonin re-uptake inhibitors to generate far greater levels of extracellular serotonin, which may cause  or death in extreme cases. Participants are advised not to take drugs unless they're sure they do not interact with MAOIs.

Where to find it

 * Iquitos, Peru (Blue Morpho is the popular spot)
 * Varillal, Peru (Caya Shobo is the only western owned center endorsed by the Shipibo Konibo Tribal Council)
 * Shimbre Shamanic Center, Tres Islas, Peru
 * Yarina, Peru
 * Pullcalpa, Peru (ceremonies with Lucho or Don Marcial)
 * Yurimaguas, Peru
 * Barrio Florida, Peru
 * Bogotá, Colombia
 * La Chorrera, Colombia
 * Mocoa, Colombia (but beware &mdash; if you die they won't give a shit)
 * Kentucky, United States of America (Aya Quest Native American Church)
 * Costa Rica, Peru, Ecuador (Retreat Directory)

Celebrity ayahuasca tourists

 * William S. Burroughs
 * Terence McKenna
 * Paul Simon
 * Sting
 * Tori Amos
 * Robin Quivers
 * Graham Hancock (his Tedx ayahuasca talk was censored)
 * Megan Fox and Machine Gun Kelly
 * Aaron Rodgers