File:1r4o.png

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Summary

Description
English: Interaction of The Glucocorticoid Receptor with DNA Edit this at Structured Data on Commons
Date 24 July 2007 (original upload date)
Source
  • Own work (Original caption: "
    Created myself using PyMol
    ")
  • Transferred from en.wikipedia by SreeBot
Author Boghog at en.wikipedia

Two crystal structures of the glucocorticoid receptor DNA-binding domain complexed with DNA are reported. The domain has a globular fold which contains two Zn-nucleated substructures of distinct conformation and function. When it binds DNA, the domain dimerizes, placing the subunits in adjacent major grooves. In one complex, the DNA has the symmetrical consensus target sequence; in the second, the central spacing between the target's half-sites is larger by one base pair. This results in one subunit interacting specifically with the consensus target half-site and the other nonspecifically with a noncognate element. The DNA-induced dimer fixes the separation of the subunits' recognition surfaces so that the spacing between the half-sites becomes a critical feature of the target sequence's identity. Reference Crystallographic Analysis of the Interaction of The Glucocorticoid Receptor with DNA Luisi, B.F., Xu, W.X., Otwinowski, Z., Freedman, L.P., Yamamoto, K.R., Sigler, P.B. (1991) Nature 352: 497-505

PubMed: 1865905 Search on PubMed DOI: https://doi.org/10.1038/352497a0 Primary Citation of Related Structures: 1GLU, 1R4O, 1R4R

Licensing

Public domain This work has been released into the public domain by its author, Boghog at English Wikipedia. This applies worldwide.
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Original upload log

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Upload date | User | Bytes | Dimensions | Comment

  • 2007-09-07 05:27 (UTC) | Boghog | 265194 (bytes) | 960×720 | Created myself using PyMol
  • 2007-07-24 19:18 (UTC) | Boghog | 193395 (bytes) | 960×720 | Created myself using PyMol

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Interaction of The Glucocorticoid Receptor with DNA

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24 July 2007

image/png

75f674706b0193de13ef6547d17450855bc17535

263,047 byte

720 pixel

960 pixel

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current08:33, 5 November 2011Thumbnail for version as of 08:33, 5 November 2011960 × 720 (257 KB)Smaug the GoldenNew version

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