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Bioidentical hormone replacement therapy

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Alternative medicine
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Clinically unproven
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Bioidentical hormone replacement therapy (BHRT) is an alternative to conventional hormone therapies. Various crackpots promote like it's some sort of magic health fairy.

BHRT prescribes hormones like progesterone, testosterone, estradiol, and estrogen for when the human body doesn't produce enough — just like normal hormone replacement therapy. The difference is that BHRT uses "natural" hormones which are extracted from plants (like yam and soy) via complex chemical processing in a laboratory — as opposed to "conventional" hormones, which are extracted from animals via complex chemical processing in a laboratory.[1]

"Bioidentical" supposedly refers to the hormones being "chemically identical" to those made by the human body itself. This is a bullshit claim, because no one has actually analyzed their chemical structure.[2][3] BHRT proponents pulled it straight out of their asses, and it's repeated over and over by its promoters[4] and, unfortunately, also by skeptics of BHRT. (Presumably "plant-derived" or "yam-based" just wasn't as marketable.)

Health claims

At first glance, BHRT's appeal is a simple "It's natural and therefore better!" argument. Advocates will probably mention that it's made from yams.

A second glance shows an incredible array of health claims being made about it. BHRT is claimed to prevent cardiovascular diseases,[5][6][7] treat osteoporosis (better than proven treatments!),[5][6][7] prevent Alzheimer's disease and eliminate depression,[5][6] prevent diabetes,[5] reverse aging,[5][6][7][8] and prevent breast cancer.[5][9]

In classic alternative-medicine-promoting fashion, BHRT advocates often mention how the therapy is tailored for each customer, while dismissing conventional therapy as "one-size-fits-all".[10]

BHRT proponents seem to target middle-aged people — the sort of people who might be looking to alleviate symptoms of menopause or adrenopause, and are wondering if hormone therapy might help. It's noteworthy how the health claims made by BHRT proponents — revolving around breast cancer, osteoporosis, Alzheimers, heart disease, and general aging — line up perfectly with the sort of health problems middle-aged people are most concerned about, despite there being zero evidence BHRT helps with any of those things.

The truth

None of the major claims about BHRT are true. There is no evidence demonstrating that BHRT is more effective than conventional treatments.[11][12] The human body can't even tell the difference between the therapies, meaning BHRT has the same side-effects and risks as conventional therapy anyways.[13][14][15]

Furthermore, quality control and dosage are major concerns; because BHRT is unregulated, no one knows exactly what chemicals, and how much of them, are contained in a given treatment.[12][16] This is made worse by the fact that BHRT is prescribed based on saliva tests, which are completely useless.[12][14][15][17]

Some BHRT businesses market their treatments in topical cream form. These are especially dubious; topical hormone creams do nothing and are basically placebos.[18][19][20][21][22]

In 2008, the FDA issued warnings to several pharmacies for making "false and misleading" health claims — the same health claims mentioned earlier on this page.[23] The FDA also notes that "bioidentical hormone replacement therapy" is a marketing term with no actual scientific or medical meaning.[24]

Even private health insurers disregard BHRT.[25]

Cost of BHRT

BHRT is expensive and, because it's an unproven treatment, rarely covered by health insurers.[26][27][28] Various BHRT clinics offer price quotes with annual costs of $1660,[29] $2000,[30] $2400,[31] even way up at $4200 per year.[32] BHRT is hardly the cheap option.

Notable proponents

Unlike with other alternative medicines, many BHRT advocates are actual medical doctors. Far from being a positive thing, this is actually pretty shameful because so many of them sell their own branded hormone treatments to patients — this is a clear conflict of interest,[2] which practicing medical doctors are supposed to avoid.

Dr. Prudence Hall, a California physician, is one such doctor.[33] In 2011 she was interviewed by Dr. Oz on Oprah about BHRT.[34] In addition to BHRT, her clinic also offers such services as the "Purity Cleanse" and the "Purity Cleanse Plus". And of course, she sells her own brand of supplements.[35]

Suzanne Somers may not be a doctor but she is a full-blown snake-oil saleswoman and a huge proponent of BHRT.[36][37] She wrote an entire book promoting BHRT as an anti-aging miracle, Ageless: The Naked Truth About Bioidentical Hormones.[38] She's also a spokesperson for foreverhealth.com, a website that sells supplements and connects patients with doctors who offer BHRT,[39] in addition to being frequently promoted by fellow crackpot medical businesses like Life Extension.[40]

External links

References

  1. ↑ "...the standard in HRT for many years, are derived from animal sources, not chemically synthesized, and thus they are arguably no less natural than those used in BHT." —Conway. Bioidentical Hormones: An Evidence-Based Review for Primary Care Providers. Journal of the American Osteopathic Association. 2011 Mar;111(3):153-64.
  2. ↑ 2.0 2.1 "...no one has put forth structural crystallographic data demonstrating structural identity with circulating human hormones... BHRT is sold by the practitioner who prescribes it, this constitutes a serious conflict of interest and violates professional ethical conduct." —Rosenthal. Ethical problems with bioidentical hormone therapy (PDF). International Journal of Impotence Research (2008) 20, 45–52.
  3. ↑ "...so-called bioidentical hormones may not be identical to the natural hormones produced in vivo by the human body." —Bhavnani & Stanczyk. Misconception and Concerns about Bioidentical Hormones Used for Custom-Compounded Hormone Therapy. The Journal of Clinical Endocrinology & Metabolism. 2012, 97:3, 756-759.
  4. ↑ There isn't a references section large enough to contain all the sites claiming that bioidentical hormones are "chemically identical" to human hormones, but feel free to check out any of the 48,000+ results in Google.
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 MyBioidenticalHormones.com claims BHRT solves cardiovascular, bone-related, mental health, and diabetes-related health problems. And of course, it does all that while making you look younger.
  6. ↑ 6.0 6.1 6.2 6.3 "Those undergoing BHRT can expect to experience an increased sense of well-being and improved energy, along with better concentration and focus skills. If you have been feeling depressed as a result of abnormal low levels of hormones, you may find the depression has lifted. ...Those undergoing therapy may also notice an increase in muscle mass, along with a reduction in body fat. If your blood pressure and cholesterol levels reached unhealthy levels, they may once again be within healthy limits. Lastly, BHRT can also reverse osteoporosis." —Blog post by a business selling BHRT.
  7. ↑ 7.0 7.1 7.2 "BHRT will substantially reduce your risk of Alzheimer’s disease and other cognitive decline. Other research has proven that BHRT significantly lessens risk of heart and blood vessel disease, osteoporosis, and (in non-smoking women) chronic obstructive pulmonary disease (COPD). It has also been proven to significantly reduce deaths from all causes in men (it’s very likely it will reduce all-cause mortality for women, too...
    Another 'perk' of BHRT is that it slows the progression of aging, including age-related changes in appearance. Women using BHRT for five to 10 years appear significantly younger than women of the same age who haven’t used BHRT.    " —Dr. Jonathan Wright. Bio-Identical Hormone Replacement ~ risks you should know and how to reduce them. VisceralSynergy.com. 2010 June 28.
  8. ↑ "Somers endorses the use of bioidentical hormones not just for the relief of menopausal symptoms but as a veritable fountain of youth." Bioidentical hormones: Help or hype?. Harvard Women's Health Watch. Harvard Medical School. 2011 September.
  9. ↑ Bioidentical Hormones: Why Are They Still Controversial? Life Extension Magazine. 2009 October.
  10. ↑ "The other difference between CHR and BHRT is that BHRT treatment regimens are custom tailored to the individual based on results of saliva or blood testing, medical history, physical exam and symptoms. CHT is a "one-size-fits-all" approach." According to one doctor's website.
  11. ↑ Boothby & Doery. Bioidentical hormone therapy: a panacea that lacks supportive evidence. Current Opinion in Obstetrics & Gynecology. 20(4):400-7. 2008 August.
  12. ↑ 12.0 12.1 12.2 May Clinic's answer to the question Are bioidentical hormones safer and more effective than hormones used in traditional hormone therapy for menopause symptoms? from the Expert Answers section at its website.
  13. ↑ "Risk accompanies therapy regardless of the chemical structure of the hormone. However, medications from compounding pharmacies—including bioidentical hormones—are not always subject to FDA monitoring for dose, purity, safety or efficacy. Inconsistency of dose and purity presents additional risk to patients." —The Endocrine Society Re-Issues Position Statement on Bioidentical Hormones. Endocrine Society. 2009.
  14. ↑ 14.0 14.1 "...natural or bioidentical compounded estrogen preparations are being promoted to consumers as safe alternatives to conventional menopausal hormone therapy and as health-promoting tonics. No reliable data support these claims.
    ...Salivary tests may be used to persuade asymptomatic consumers to use hormones (or symptomatic patients to use higher doses than those needed to mitigate symptoms), a practice that can be expected to result in adverse events.    " Fugh-Berman & Bythrow. Bioidentical Hormones for Menopausal Hormone Therapy: Variation on a Theme. Journal of General Internal Medicine. 22(7): 1030–1034. 2007 July.
  15. ↑ 15.0 15.1 "Advocates claim that bioidenticals are safer than pharmaceuticals, but since they are essentially the same compounds, there is every reason to think they would have the same side effects.
    ...dosage is usually guided by salivary hormone levels, which are unreliable. Suzanne Somers even advocates that the patient adjust her own dosage from day to day just depending on how she feels.    " Harriet Hall. Bioidentical Hormones. Science-Based Medicine. 2010 June 29.
  16. ↑ "Among the 12 prescriptions we filled, estriol was sub-potent in all samples, meaning that the hormone was present in lower quantities than the prescription label indicated. In all but two cases, the other two estrogens in Tri-Est, estrone and estradiol, were superpotent—they delivered a higher dose than prescribed." —Investigative report on BHRT by More magazine.
  17. ↑ "salivary testing of a woman's hormone levels is not useful because they vary within each woman depending on her diet, time of day, the specific hormone being tested, and other variables. Although monitoring salivary hormone levels is promoted by some as a means of 'tailoring' a hormone treatment to an individual, hormone therapy does not require customized dosing." —ACOG Reiterates Stance on So-Called "Bioidentical" Hormones. American Congress of Obstetricians and Gynecologists. 2009 February 3.
  18. ↑ Elshafie & Ewies. Transdermal natural progesterone cream for postmenopausal women: inconsistent data and complex pharmacokinetics. Journal of Obstetrics and Gynaecology. 2007 Oct;27(7):655-9.
  19. ↑ Benster, et al. A double-blind placebo-controlled study to evaluate the effect of progestelle progesterone cream on postmenopausal women. Menopause international. 2009 Jun;15(2):63-9.
  20. ↑ "So-called natural, plant-derived progesterone creams sold over the counter contain too little of the hormone to be effective. And yam extract creams don’t help because your body cannot convert them into progesterone." —What are bioidentical hormones?. Harvard Women's Health Watch. 2006 August.
  21. ↑ "...about the use of progesterone creams, particularly regarding the efficacy of yam-based or other plant-based creams. ...wild yam (Dioscorea barbasco) cannot be converted into progesterone in the body." —One (admittedly pro-BHRT) doctor discussing hormone creams.
  22. ↑ Another pro-BHRT doctor admitting that topical hormone creams are goddamned useless.
  23. ↑ FDA Takes Action Against Compounded Menopause Hormone Therapy Drugs. U.S. Food and Drug Administration. 2008 January 9.
  24. ↑ "'BHRT' is a marketing term not recognized by FDA." Bio-Identicals: Sorting Myths from Facts. U.S. Food and Drug Administration. 2008 April 8.
  25. ↑ Official Blue Cross Blue Shield web page bluntly noting that BHRT doesn't do any of the things it's claimed to do.
  26. ↑ "The trouble was that BHRT usually isn’t covered by insurance. It’s definitely not covered by mine and it’s quite costly. Especially the lab work that you have to get before the therapy even begins." —Jennifer Jaynes. Journey with Bioidentical Hormone Replacement Therapy: Day 16. Project Jennifer. 2011 April 6.
  27. ↑ "Typically, BHRT (implants and insertions) is not covered by insurance companies." —As stated by this BHRT clinic.
  28. ↑ "since BHRT is considered 'alternative therapy', it is usually not covered." —Another clinic discussing its own BHRT.
  29. ↑ See BioBalance Health's own price list. Not counting the initial consultation fee of $200 or more and using the cheapest possible options, their BHRT regimen has an annual cost of $1660.
  30. ↑ See this comment where someone claims they relied on BHRT, learned it wasn't covered by their insurance, and it ended up costing them $2000.
  31. ↑ BodyLogicMD, which heavily promotes BHRT, quotes its cost at $2400 a year.
  32. ↑ Griffon Medical Group, which specializes in anti-aging and BHRT, flat-out states that it can cost up to $350 per month, and that insurance doesn't cover it.
  33. ↑ Dr. Hall's webpage.
  34. ↑ From the Oprah show archives: Dr. Oz talks with Dr. Prudence Hall, a proponent of bioidentical hormone replacement therapy.
  35. ↑ Dr. Hall's store.
  36. ↑ Deborah Kotz. Why Suzanne Somers Loves Bioidentical Hormones. U.S. News & World Report. 2009 March 25.
  37. ↑ Barron H. Herner. Suzanne Somers, Cancer Expert. New York Times. 2011 February 25.
  38. ↑ Suzanne Somers. Agless: The Naked Truth About Bioidentical Hormones. Crown Publishers, 2006.
  39. ↑ Forever Health page on Somers' website.
  40. ↑ A search of Life Extension's website reveals 58 mentions of Somers in their magazine, across 11 years worth of issues.
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