RationalWiki's Q4 2016 Fundraiser
We are 100% user-supported!
Without you, there is no RationalWiki!
Goal: $5000 Donations so far: $4910
98.2%

Fighting pseudoscience isn't free.
Help and donate today!

Bronze-level articleLupron therapy

From RationalWiki
Jump to: navigation, search
Against allopathy

Alternative medicine

Icon alt med alt.svg
Unproven articles

Lupron therapy is a discredited treatment for autism, based on the false premise that autism is related to vaccination, mercury, hormones, and gut integrity.

Contents

[edit] Origins

Leuprorelin

The idea seems to have originated ex culo, or, rather, from the "minds" of Mark and David Geier, a father-son team who peddle chelation and Lupron therapy to families with autistic children. Lupron[wp] (known as leuprorelin or leuprolide acetate) is a potent anti-androgen. It is used as a form of "chemical castration" for men with prostate cancer, for women with uterine fibroid tumors, and in a few other rare medical situations. The Geiers assert that thimerosal, a mercury-containing preservative often used in vaccines in the 20th century[1], causes autism, and that chelation therapy can remove it. They claim that testosterone binds with mercury in such a way as to prevent chelation; to combat this, they prescribe Lupron, which supposedly reduces testosterone levels and thereby enables chelation.[2]

[edit] Quackery

[edit] Invalid starting hypothesis

As discussed elsewhere, the thimerosal-autism hypothesis has been disproved, as has chelation therapy for autism.

[edit] Shady methods

The Geiers publish in less-than-respectable journals that avoid peer review. They appear to have set up a sham "institute" in order to form an IRB (institutional review board) consisting of friends and supporters, in order to conduct research on human subjects without the usual oversight.[3]

[edit] Lack of scientific support

The scientific community has not embraced the Geiers' cause. A Medline search of "autism and leuprolide (Lupron)" returns only four hits, two of which are from the Geiers.[4]

[edit] Summary

Treatment of autism with Lupron is not only scientifically bankrupt, it is also irresponsible and dangerous. It is based on false premises and is unsupported by scientific evidence.

  1. Thimerosal and mercury are not proven to cause autism.
  2. Androgens are not proven to potentiate this unproven association.
  3. Chemical castration of children has not been shown to help with autism.

It is reasonable to posit that androgen deprivation in children, especially, but not exclusively males, may have profound biological and behavioral effects. Creating eunuchs may be good for business, but it is bad medicine.

[edit] External links

[edit] See also

[edit] Footnotes

  1. FDA.gov
  2. Geier MR, Geier DA.The potential importance of steroids in the treatment of autistic spectrum disorders and other disorders involving mercury toxicity. Medical hypotheses. 2005; 64(5):946-54.
  3. Geier DA. Geier MR. A clinical trial of combined anti-androgen and anti-heavy metal therapy in autistic disorders. [Clinical Trial. Journal Article. Research Support, Non-U.S. Gov't] Neuroendocrinology Letters. 27(6):833-8, 2006 Dec.
  4. autism and leuprolide (Lupron) - PubMed - NCBI


Personal tools
Namespaces

Variants
Actions
Navigation
support
Community
Tools