| Style over substance|
Water memory is one of the concepts central to modern (i.e., post-Avogadro) homeopathy.
Due to the nature of the dilutions in a homeopathic preparation, no molecule of any active ingredient remains in the final product. To get around this fact, homeopaths fall back onto the idea that the solution somehow retains a "memory" of the solute. Although it is possible to argue that only proof of efficacy in homeopathic preparations is important, water memory has become an essential element for anyone trying to offer up rationalizations for a mechanism of action. To highlight its importance the homeopath apologist's journal Homeopathy recently devoted a whole issue to water memory.
This idea takes many forms, each of which is less plausible than the last.
Jacques Benveniste proposed water memory in the 1980s, and famously managed to publish some of his results in the journal Nature, for which he earned the first of his two Ig Nobel prizes. Lacking any objective grounds to reject the seemingly impossible paper through the process of peer review (so the many claims that established science merely rejects quack ideas with a closed mind are patently false), the paper was sent to press. The journal's editor John Maddox, however, remained skeptical and allowed the results to be published accompanied by a small editorial on the subject by himself, stating in the piece the number of laws of physics and chemistry such a result would violate and that "There are good and particular reasons why prudent people should, for the time being, suspend judgment." The only other remaining condition was that the research mentioned was independently replicated following publication and the controversy created a small media storm in 1988. The team sent to investigate Benveniste's claims included James Randi - whose expertise on sleight of hand and fraud detection were put to use in the lab. The report from the team concluded that although Benveniste was innocent of academic misconduct and fraud, he had been misled by flawed experiments. Thus, one of homeopathy's most shining moments was tarnished, and even John Maddox was almost disappointed, concluding "I'm sorry we didn't find something more interesting."
|“|| Water has memory!
And while its memory of a long lost drop of onion juice is Infinite
—Tim Minchin - Storm
The central principle of homeopathy is that like cures like. So homeopaths seek out dangerous herbs and other ingredients that produce symptoms of disease (such as nightshade, arsenic, and strychnine) and use these in their preparations. Since this would normally kill the patient, the homeopath uses a series of dilution procedures, known as succussion, to dilute the solution so much that any given sample will not contain any of the original ingredients. While most people realize that diluting decreases potency, the homeopath claims the exact opposite - that the more diluted the preparation is the stronger it is. This potency-increasing dilution also magically removes the side effects of the original poison.
Homeopaths have failed to prove the efficacy of their treatments after many experimental attempts. Given the complete and utter failure of experimental evidence, many have turned to trying to create mechanistic explanations for how homeopathy could work. These "proof of principle" ideas revolve around finding an explanation for how diluting a solute can increase its effect. The current vogue idea is "water memory": the homeopath believes that their dilution process somehow transfers the properties of the solute to the water molecules themselves, then those molecules of water transfer it to new water and on and on. They propose this as the explanation for the a priori belief that diluting increases potency.
Homeopaths, true to form, have not really tried to prove that there even is such a thing as water memory. One cogent example of this is that James Randi has offered his million dollar paranormal challenge money to anyone that can prove water memory exists. No major homeopathic practitioner or company has taken him up on the offer - with the exception of Randi's involvement with the Benveniste case in 1988, which was partially funded by the French Homeopathy Council. However in 1999, Madeleine Ennis of Queen's University of Belfast had claimed to have replicated Benveniste's miraculous findings (those debunked by John Maddox and James Randi a decade earlier). In 2002 the BBC pop science program Horizon did an on-air test replicating this work with Randi to attempt to win the prize. The replication failed completely, with the documentary concluding "Homeopathy is back where it started without any credible scientific explanation. That won't stop millions of people putting their faith in it, but science is confident. Homeopathy is impossible."
Since the starting premise in most research on water memory is that it is a fact, an explanation must be sought. There are no analogous situations in the natural world, so unique lines of reasoning have been developed to explain a phenomenon that has never been proven to exist. With no actual data on water memory or how it behaves (since they haven't even proved it exists!), researchers can make up whatever they feel like as long as it sounds nice and not have to be worried about testing or making predictions. This is a big reason why this fraud is the epitome of pseudoscience.
Ideas presented by homeopaths
Homeopaths present many odd ideas to try to explain the mechanism behind the phenomenon of water memory. Since water memory has not yet been proven to exist, the hypotheses are a bit premature. Examples include:
Modeling water memory
One of the most clear cut examples of how water memory researchers work from assuming their conclusion is in the realm of mathematical modeling. A recent example was published in the aforementioned water memory issue of homeopathy. The author of this paper took a list of assumed properties of water memory based around assumptions of homeopathy and then constructed a mathematical model that described these assumptions. In the paper, the author has no physical experimentation in which to ground his model and no logical constraints other than "it makes the equation do what I want" for most of his manipulations. Exponentials and terms are randomly dropped into the model with the only explanation being that they were required to make the math work. Mark Chu-Carroll of scienceblogs has a full refutation of the work at his site.
The amazing thing about this is that this - which isn't particularly clever or conclusive by the normal standards of science - is considered cutting-edge research in the world of alternative medicine. There is no empirical grounding for this research (and as Richard Feynman said, "It does not make any difference how smart you are, who made the guess, or what his name is – if it disagrees with experiment it is wrong.") or logical constraints at all. This is, frankly, terrible science, yet it's the best that research into these extraordinary claims has to offer. It is no wonder that so few people take this stuff seriously. It's completely baffling how anyone can.
Problems with water memory
Thermodynamics of water memory
According to thermodynamics, the thermodynamic functions (enthalpy, entropy, etc.) of a substance are determined only by the current state of the system, in terms of its pressure, temperature, volume, etc. Included in this is the distribution of velocities and internal vibrations and rotations. Thermodynamics has shown that how one reaches these states is independent of the path to the state; that is, there is no "memory" of former temperatures, pressures, etc. or dissolved substances. If water did have a memory, it would be an example of a Nobel prize winning concept, as it would violate current thermodynamic concepts.
There are such forms of substances that are thermodynamically unstable or "metastable" (such as supersaturated solutions or allotropes of elements) that exist that are prevented kinetically from approaching thermodynamic stability because of a lack of a pathway. However, water has relatively weak hydrogen bonding as intermolecular forces (relative to covalent bonds) that are easily overcome at room temperature and very short-lived. Once a solute is removed from the water, the water will rapidly come to equilibrium and all evidence that the solute was ever in the water will be gone.
Various physical properties of water can be altered by small amounts of dissolved substances; these properties are called "colligative properties," and have been explored in great detail by physical chemists. Hence, the purity of the water, including dissolved gases, is paramount in determining physical properties. There are clusters of water molecules as well as hydronium ions, hydroxide ions and associated hydrogen bonded species of these ions; however, there is no evidence that these exist over macroscopic scales as suggested by the water memory enthusiasts. Water memory also likely violates the principle of microscopic reversibility.
Tap water of death
One of the interesting questions with water memory is why billions of people worldwide drinking out of natural and tap sources of water are not dropping dead of overdoses. One environmental watchdog group has documented over 500 chemicals in an average glass of tap water, many of which are used in homeopathic treatments. The EPA of course sets maximum concentration for these chemicals in water, and over time the maximum concentration has decreased considerably. Many people consider that as a way of making tap water safer to drink, but to the homeopath that's actually making it worse! More dilution equals stronger effect.
Most homeopaths seem to ignore this consequence of their theory or offer post-hoc rationalizations such as succussion being needed to "potentiate the solution". If water truly had a memory then city tap water would be one of the most dangerous substance on the planet. However, many others see this as a prime opportunity to make even more money. Various products and magic cleansing waters are sold over the Internet to eliminate these toxins with prices exceeding a thousand dollars.
If your friends insist on water memory, next time you have a drink give them the emptied beer or wine bottles filled with water. They'll be drunk in no time...
The completely unscientific nature of these hypotheses has been explored elsewhere, but they have a number of flaws in common. All start with the assumption that the phenomenon in question actually exists, and moves from there to try to find a reason why. None of these reasons have any scientific plausibility. Furthermore, the experiments fail to provide adequate control and rigorous determinations of purity, and fail to assess error in the measurements. The proponents also give possible explanations of the phenomenon without any link between their "data" and the proposed physical explanations. Explanations include increased or decreased levels of hydrogen bonding; macroscopic clustering of water molecules; and polymerization (which is impossible).
- Science Blogs - Your Friday Dose of Woo: A homeopathic journal club
- Science Blogs - Bad Homeopathic Differential Equations. Yech.
- Science Blogs - Your Friday Dose of Woo: It's not just homeopathy, it's quantum homeopathy!
- Ars Technica - Diluting the scientific method: Ars looks at homeopathy
- Wikipedia on water memory - A decent coverage of the study published in Nature towards the end of the 1980s.
- Can we please forget about water memory (blog March 2013)
- Homeopathy. Volume 96, Issue 3 pp. 141-230 (July 2007).The Memory of Water
- J. Benveniste et. al. Nature 333: 816–818.
- When to believe the unbelievable, Nature 333, 787 (1988)
- Time Magazine - The Water That Lost Its Memory (Paywall-free archive)
- Shang et. al., The Lancet (2005), 366, 9487, 726-732
- BBC - Homeopathy: The Test (transcript)
- David J. Anick and John A. Ives. The silica hypothesis for homeopathy: physical chemistry. Homeopathy. Volume 96, Issue 3, July 2007, Pages 189-195 The Memory of Water
- Vladimir L. Voeikov. The possible role of active oxygen in the Memory of Water. Ibid Pages 196-201.
- India Times
- David J. Anick. The octave potencies convention: a mathematical model of dilution and succussion. Volume 96, Issue 3, July 2007, Pages 202-208 The Memory of Water.
- Mark Chu-Carroll's refutation of homeopathic math
- Nature - Ultrafast memory loss and energy redistribution in the hydrogen bond network of liquid H2O
- National tap water quality database
- Why is succussed water OK, but products of chemical reactions (like baking soda with vinegar) are synthetic?
- Second only to water-cooler water, which tends to be distilled -- diluting its impurities to an even greater potency -- and then delivered by a truck whose trailer probably has only a weak suspension to protect it from accidental succussion.
- Magic water woo machine
- Magic cleansing water ECH20!